Rheumatoid Arthritis
Rheumatoid arthritis or RA is an inflammation of the synovium in joints, with 1 to 2% of the population occurs. Are also regularly tendon sheaths and sacs in the inflammatory process. The term includes the people rheumatological foot (and in the terminology of the rheumatism foundation) many diseases. Rheumatoid arthritis, osteoarthritis, fibromyalgia, the disease Bekhterev and gout are a few examples. For doctors’ rheumatism ‘, however, usually a specific indication for rheumatoid arthritis.
A general aetiological or pathogenetic factor that a priori gives rise to the emergence of RA has not yet been found. The symptoms are caused by the formation of lysosomal enzymes (enzymes or degrading hydrolytic enzymes) that the spot produced by cells of the immune system, therefore, is an autoimmune process. This looks like a type IV hypersensitivity reaction, because of the involvement of CD4 T-cells (Th1 and Th2 cells) and that of CD8 cytotoxic T-cells, respectively, in the promotion of destruction by macrophages and B cells of the immune system and apoptosis (programmed cell death ). Although many in the very population that they have disorders with ‘rheumatism’ attention, RA is relatively rare in the strict sense, and is associated with all inflammatory reactions: pain / swelling / heat / redness and function loss and concrescence of the affected joints. In addition to RA joints can, however almost all organ systems affected. Most people with RA may, with the current state of treatment is a fairly normal life. However, a small group of patients who are seriously interested in the long term valid upgraded touches.
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